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Diagnosis for Dengue

A mosquito-borne disease that occurs in tropical and subtropical areas of the world is called dengue. There are symptoms like high fever, rash and muscle and joint pain during this fever caused by dengue viruses. If the dengue fever turns to dengue hemorrhagic fever, it can cause severe bleeding, a sudden drop in blood pressure (shock) and death. In India, many cases of dengue occur every year.

The signs and symptoms of dengue often resemble those of other diseases like malaria, leptospirosis and typhoid fever. If you have the symptoms of dengue, the doctor will examine your medical history and ask you some questions. There are certain diagnostic tests, which can detect the presence of dengue viruses. You can contact the diagnostic centers in Uttarpara for various tests for the detection of dengue viruses.

1. MAC-ELISA

The pathologist can measure a rise in dengue-specific IgM during primary or secondary dengue infections. It can be done even in sera samples, which a pathologist collects at 1-day to 2-day intervals in the acute phase. The tests done against a panel of antigens can help in the diagnosis of acute or recent dengue infection as anti-flavivirus IgM is complex-specific.

2. IgG ELISA

For the detection of recent or past dengue infections, the pathologist uses the IgG ELISA test. The same antigens as the MAC-ELISA are in use during this assay. The doctor can detect IgG antibodies over a period of 10 months after the infection if the pathologist uses E/M-specific capture IgG ELISA (GAC).

3. Total White Blood Cells Count

This test will reveal leucopenia in the case of dengue. If there is the presence of leukocytosis and neutrophilia, the doctor can exclude the possibility of dengue. This test is done in a pathology lab in Uttarpara, Hooghly.

4. Thrombocytopenia (less than 100,000 per mm3)

In every patient with symptoms suggestive of dengue for three or more days of presentation, the pathologist performs tests to obtain total platelets count.

5. Hematocrit (micro-hematocrit)

It’s necessary to know the presence of hemoconcentration (hematocrit elevated by more than 20%). We must regard as significantly elevated if the results are more than 45% when it is not possible to know the previous value of hematocrit.

6. IgM/IgG ratio

The doctor can distinguish primary from secondary dengue virus infections by examining a dengue virus E/M protein-specific IgM/IgG ratio. The most common assays for this purpose are IgM capture and IgG capture ELISAs.

7. IgA

It often occurs one day after that for IgM that there is the measurement of positive detection for serum anti-dengue IgA by anti-dengue virus IgA capture ELISA (AAC-ELISA).

Besides the above ones, there are many other tests for dengue

2019-09-11T08:01:07+00:00